Science Library

One of the most cited C60 studies. Rats administered C60 in olive oil showed altered oxidative stress markers compared to controls. The study's findings on lifespan in rodents generated significant scientific interest and debate. Results apply to the specific rat model used and cannot be directly extrapolated to humans.

This in vivo rat study investigated water-soluble C60 fullerene administered at doses of 0.5, 1, and 2 mg/kg over 3–9 months in rats with chronic alcohol intoxication. The optimal dose of 1 mg/kg produced up to 29% improvement in liver enzyme and antioxidant markers, with histopathological analysis confirming reduced pathological changes. These findings relate to a specific rodent model of alcohol-induced liver injury and cannot be extrapolated to humans.

Explored the potential neuroprotective properties of carboxyfullerene derivatives in cell and animal models. The study examined interactions with free radical-mediated neuronal damage in vitro. These findings relate to chemically modified C60 derivatives, not plain C60 oil.

This experimental study examined the antioxidant and hepatoprotective potential of C60 fullerene in a rodent model of oxidative stress, measuring key markers of lipid peroxidation and enzymatic antioxidant defence. Results demonstrated significant attenuation of oxidative damage parameters in treated animals compared to controls. These findings are limited to the specific animal model used and direct application to human health has not been established.

This study developed a nanoemulsion carrier system incorporating fullerene as a free radical scavenger and assessed its effects on collagen and skin hydration after 28 days of twice-daily topical application. Results showed a 33.29% improvement in collagen scores and a 43.12% increase in skin hydration, with no observed acute toxicity or dermal irritation in tested cell models. These findings relate to a specific formulated nanoemulsion and human clinical evidence for anti-aging benefits has not been established.

This review examines the diverse medicinal applications of fullerenes, focusing on their antioxidant, antiviral, and drug delivery properties. The authors highlight C60's capacity to scavenge free radicals, fit inside the hydrophobic cavity of HIV proteases, produce singlet oxygen for photodynamic therapy, and act as a carrier for gene and drug delivery systems. The review covers preclinical findings only; robust human clinical data for these applications has not been established.

This study applied a fullerene-C60-in-squalane preparation to human skin cell cultures and three-dimensional skin tissue models, assessing protection against lipid radical-induced cellular damage and wrinkle formation. The C60 formulation restored cell viability significantly and reduced structural skin damage compared to untreated controls. These findings relate to in vitro skin models and do not constitute human clinical evidence.

This review examined how polyhydroxylated fullerenes (fullerenols) may protect neural tissue against ferroptosis-driven neurodegeneration, with a focus on multiple sclerosis models. The authors propose that fullerenols suppress ferroptosis via inhibition of lipid peroxidation, free radical scavenging, and modulation of the NRF2 signalling pathway. These findings are preclinical; no completed clinical trials have been reported and translational relevance to humans has not been established.